Bye Cancer

Semenogelin is the key





Cancer-related enzymes



LDHA

Contributes to the aerobic glycolysis (Warburg effect), which is associated with aggressive, poor differentiated, metastatic tumors, resistance against chemotherapy, and shortened patients survival



PKM2

Is the critical enzyme for glycolysis. PKM2 diverts glucose-derived carbons from catabolic to anabolic (biosynthetic) pathways, which is a hallmark of cancer



SEMGs and Cancer

We found that SEMG1 interacted with both LDHA and PKM2, whereas SEMG2 interacted with PKM2 only

Piruvato quinasa M2 (PKM2) y lactato deshidrogenasa A (LDHA)

SEMG1 and SEMG2 genes belong to the family of cancer-testis antigens (CTAs), whose expression normally is restricted to male germ cells but is often restored in various malignancies. High levels of SEMG1 and SEMG2 expression are detected in prostate, renal, and lung cancer as well as hemoblastosis.

However, the functional importance of both SEMGs proteins in human neoplasms is still largely unknown.

We have demonstrated that SEMG1 and SEMG2 are frequently expressed in lung cancer clinical samples and cancer cell lines of different origins and are negatively associated with the survival rate of cancer patients.

Using the pull-down assay followed by LC-MS/MS mass-spectrometry, we have identified 119 proteins associated with SEMG1 and SEMG2. Among the SEMGs interacting proteins we noticed two critical glycolytic enzymes-pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA).

Importantly, we showed that SEMGs increased the protein level and activity of both PKM2 and LDHA. Further, both SEMGs increased the membrane mitochondrial potential (MMP), glycolysis, respiration, and ROS production in several cancer cell lines. Taken together, these data provide first evidence that SEMGs can up-regulate the energy metabolism of cancer cells, exemplifying their oncogenic features.



Message

Spermatozoa (spermatozoon cells)

Padlock

Semenogelin (SEMG1/SEMG2) (ROS) generation FROM Seminal vesicles

Key

Prostate-specific antigen (PSA) FROM Prostated gland (epithelial cells)



Treatment


  1. Add semelogelin liquid and hold for a few minutes to generate apoptosis of all damaged cells.
  2. Remove the liquid and toxins that were produced by generating cell death through the suicide gene, in this case semelogelin.
  3. Mix viscous mucus (mucin) with hydroxyapatite and oxygen.
  4. Add the mixture to the area damaged by the cells. Hold for a few minutes and then remove. This mixture helps with the healing and regeneration of affected tissues helping to diminish the neoplasia generated by the cells that have already been removed thus avoiding future recurrence.


* The time that both liquids should be applied depends on the damage.



ComponentSourceFunction
Semenogelins (SEMG1/2)Seminal vesiclesGel semen, regulate viscosity; oncogenic in cancers via metabolic enzyme interaction
PKM2 and LDHACancer cellsGlycolytic enzymes promoting Warburg effect and tumor progression
Prostate-specific antigenProstate glandLiquefies semen by breaking down semenogelins
Hydroxyapatite (HAP)Teeth enamelSupports tissue regeneration and repair
MucinGoblet cells in epitheliaProvides mucus viscosity and protection


Sources

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Thanks to all humans and non-humans who contribute.


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